Southern Cross may refer to:
- Robotech: The Robotech Masters, the second saga of Robotech, which is referred to as Southern Cross in the old Robotech: The Roleplaying Game
- The Army of the Southern Cross, a command of the United Earth Forces
- A southern constellation from Earth's perspective, in which direction the Robotech Masters' homeworld (Tirol) can be found.
- Southern Cross (episode), The 39th episode of Robotech and 3rd episode of the 2nd saga.
- Southern Cross (novel), the Jack McKinney novel.